MPS Study

Call for Collaboration

Mucopolysaccharidosis (MPS) is a group of rare genetic disorders characterized by the accumulation of mucopolysaccharides, also known as glycosaminoglycans (GAGs), in various tissues and organs throughout the body. These disorders are caused by a deficiency in specific enzymes responsible for breaking down GAGs, leading to their buildup within cells and causing progressive damage. There are several types of MPS, each with its own set of symptoms and severity levels, but they all share some common features.

Assessing pediatric bone age is crucial for individuals with MPS because it helps healthcare providers monitor the progression of skeletal abnormalities. As MPS primarily affects the skeletal system, assessing bone age through X-rays and other imaging techniques allows medical professionals to track the advancement of bone deformities and plan appropriate interventions. Regular bone age assessments also aid in determining the timing of specific treatments and surgeries, ensuring that they are carried out at the most beneficial stage of the disease.

Deeplasia for MPS

In our first study, we assessed the performance of Deeplasia for measuring the bone age of children with eight different skeletal disorders. We found that Deeplasia's measurements are in very good agreement with the average of two expert clinicians with decades of experience in pediatric bone age assessment.

In a next study dedicated to MPS, we aim at investigating the performance of Deeplasia for bone age assessment of children with MPS.

We invite all the interested clinicians and researchers to join this study.

Coordinating scientists:

Prof. Dr. med. Klaus Mohnike University Hospital Magdeburg, Germany Send E-mail
Ms. Minu Fardipour University Hospital Magdeburg, Germany Send E-mail